Blue baby syndrome*** "complicated disease"

Blue Baby Syndrome *** "God's curse or boon"

  After all, is it blue baby syndrome?  How many times we must have read these words in books and have not even seen many times on the internet, do you know that this blue baby syndrome is ultimately a disease or a symptom of human body which is blue in color?  Let us go into detail about all these things.
 I hope that I can explain this unique unsolved puzzle of science in front of all you readers,

 In medical terminology, there are some boys with whom destiny plays such a game that their little heart becomes prey to some malformations during pregnancy itself that show their deeds only after birth, for example, these unfortunate people get oxygen-rich blood.  The supply has not been maintained properly.  Their blue skin blood is the result of this deoxygenated state.  The color of the blood becomes red only when it gets full oxygen, its oxygenation properly.

 Normally in our four-roomed heart, this arrangement is carried out in a self-propelled manner, the left cell (or heart chamber or ventricle) carries oxygenated blood, the oxygen deprived blood in the right which is returned by visiting all the tissues and cells  .


 Sometimes Cyanotic Child or Blue Baby are also called unlucky people whose lungs are not able to do the normal work of providing oxygen to the blood.

 *** Cyanotic means blue. ***

 Second reason

 Another medical condition arises from the use of such groundwater in which the quantity of nitrates has been found to be higher than the standard accepted quantity.  It is worth noting that due to the unabated use of many chemical fertilizers, these nitrates are continuously contaminating ground water from all the aquifers by leaking out of urban debris buried in the land in the city square, Pit latrines.  Just leave some developed nations where people are now taking over.


 The digestive system of infants converts these nitrates into nitrite, the same nitrite reacting with oxyhemoglobin in the blood and affecting it to metha-globin.  This metha-globin cannot become a vehicle of oxygen.  While oxy-hemoglobin, which is an efficient vehicle of blood protein hemoglobin, is released.  It is due to this protein that the color of the blood remains red, due to which, in the absence of it, it begins to take blue, which appears in the outer organs of the skin and affected cyanotic baby.  The fingers and nails are also affected by this deformity.  In this case, the nail plate's curvature, curvature or convexity increases.
  Blue Baby Syndrome in Children Their Skin Color
 Blue baby syndrome is a condition in which some babies are born at birth or develop early in life.  It is characterized by a composite skin color with blue or violet color, called cyanosis.
 This blue appearance is most noticeable, where the skin is thin, such as lips, earrings, and nail beds.  Blue baby syndrome, while not common, can be caused by a number of congenital (present at birth) heart defects or environmental or genetic factors.

 *** What is blue baby syndrome?

 Due to poor oxygenated blood, the child becomes a blurred color.  Normally, blood is pumped from the heart to the lungs, where it receives oxygen.  The blood circulates back to the heart and then throughout the body.
 When there is a heart, lung, or blood problem, the blood may not be properly oxygenated.  Due to this, the skin color turns blue.  Lack of oxygen can occur for many reasons.

 Tetralogy of Fallot (TOF)

 While a rare congenital heart defect, TOF is a primary cause of blue baby syndrome.  It is actually a combination of four heart defects that can reduce blood flow to the lungs and allow oxygen-poor blood to flow out into the body.
 TOF involves conditions such as holes in the wall that separate the left and right ventricles of the heart and disrupts the flow of blood from the right ventricle into the pulmonary, or lung, artery.

 Methemoglobinemia

 This condition stems from nitrate poisoning.  This can occur in infants who are fed infant formula, which includes well-mixed water or homemade baby food containing nitrate-containing foods such as spinach or beets.
 This condition often occurs in infants under 6 months of age.  When it is young, infants have more sensitive and underdeveloped gastrointestinal tracts, which are more likely to convert nitrate to nitrate.  As nitrite spreads throughout the body, it produces methemoglobin.  While methemoglobin is oxygenated, it does not release that oxygen into the bloodstream.  It gives infants with their blue color status.
 Methemoglobinemia can also rarely be congenital.

 ** Other congenital heart defects **

 Genetics cause most congenital heart defects.  For example, infants born with Down syndrome often have heart problems.
 Problems with maternal health, such as underlying and poorly controlled type 2 diabetes, can also result in reduced child development.
 Some heart defects also occur without any apparent cause.  Only a few congenital heart defects cause cyanosis.

  *** What are the symptoms of Cyanosis ***

 # In addition to the blue color of the skin, other symptoms of blue baby syndrome include:

 # Irritability

 # Sluggishness

 # Feeding Issues

 # Inability to gain weight

 # Developmental issues

 # Fast heartbeat or breathing

 # Club (or round) fingers and toes

 ***** How is it diagnosed? ****

 In addition to taking a thorough medical history and performing a physical examination, your child's pediatrician will likely perform several tests.  These tests will help determine the cause of blue baby syndrome.  Tests may include:

 #blood test

 # Chest X-ray to check the size of lungs and heart

 # Electrocardiogram (EKG) to see the electrical activity of the heart

 # Echocardiogram to see the anatomy of the heart

 # Cardiac catheterization to visualize the arteries of the heart

 # Oxygen saturation test to determine how much oxygen is in the blood

 ***** How is it treated? *****

 Treatment depends on the cause of blue baby syndrome.  If the condition is created by a congenital heart defect, your child will most likely need surgery at some point.
 Medication may also be recommended.  These recommendations are based on the severity of the defect.  Children with methemoglobinemia can reverse the condition by taking a drug called methylene blue, which can provide oxygen to the blood.  This medicine requires a prescription and is usually inserted into a vein via a needle.

  **** How Can I Stop Blue Baby Syndrome? ****

 Some cases of blue baby syndrome are a streak of nature and cannot be stopped.  Others, however, can be avoided.  Steps to include:

 Do not use water well.  Unless they prepare a child over 12 months of age with well water or water well for drinking.  Boiling water will not remove nitrates.  Nitrate levels in water should not exceed 10 mg / L.  Your local health department can give you more information about getting the water tested well.

 Limit nitrate-rich foods.  Foods rich in nitrate include broccoli, spinach, beets and carrots.  Limit the amount you feed your baby before the age of 7 months.  If you make your child a meal and should use these vegetables, use frozen instead of fresh.

 Avoid illegal drugs, smoking, alcohol and some medicines during pregnancy.  Avoiding these will help prevent congenital heart defects.  If you have diabetes, make sure that it is well controlled and that you are under the supervision of a doctor.

 ****** What is the approach for infants with this condition? ****

 Blue baby syndrome is a rare disorder for various reasons.  Your doctor can recommend anything from immediate treatment to surgery.  Surgery can be very risky when performing surgery on a newborn.
 Once the cause is identified and successfully treated, most children with Blue Baby Syndrome can lead normal lives with few health consequences.

  **** Genetic association with "Blue Babies" *****

 By Bethan Hormatka, Ph.D .;
 New research suggests that a once fatal congenital heart defect - sometimes referred to as "blue baby syndrome" - is influenced by genetic factors that are largely found in the general population.
 Various heart pathologies lead to poor oxidation of blood and a blemish disintegration of the skin, but the most common culprit (affecting three in 10,000 births) is a condition known as fallot (Fe-LO), or tetralogy of TOF.  The first heart surgery for this condition was pioneered in the mid-1940s, with nearly 80 percent of affected children dying before the age of ten.

 **** genetic factors and non-genetic factors ****

 Like most heart pathologies arising in the womb, it is not possible for TOF to indicate a causative factor.  Many non-genetic factors increase the risk - alcoholism and diabetes in the mother as well as poor nutrition during pregnancy and some infections.
 But there are also indications that TOF is more common in some families, raising the possibility that genetics also play a role.

 "A new study on TOF"

 Dr. from the Institute of Genetic Medicine in Newcastle.  The new study led by Heather Cordell provides insight into the genetic superstructure of TOF.  Dr.  Cordell and his colleagues performed the first genome-wide association study (GWAS) on this condition on approximately 1,600 people of European ancestry and two genetic variants associated with TOF were found.  Their findings were published in the journal Human Molecular Genetics.
 The first variant is located in the region of chromosome 12 (12q24) previously associated with many complex conditions including coronary artery disease and autoimmune disease.  The second variant is located in a gene called GPC5 that encodes a protein called glypican 5.

 Other previously identified variants

 Previous studies have associated near deletions of this gene with heart pathologies including TOF.  Some other markers were also spontaneously linked to TOF and it is possible that in future, larger studies may strengthen their participation.
 This is the first study to suggest that common genetic factors in the developing fetus play a role in TOF.  Roughly 30 percent of people have at least one risky version of the SNP discussed here, but each version only slightly increases the risk.  Combine these genetic factors with environmental signals and the scale may move towards TOF.